Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ SNX-482
A peptidyl toxin from venom of African tarantula, Hysterocrates gigas that acts as a high affinity, reversible blocker of Cav2.3 (α1E, R-type) channels (IC50 = 15-30 nM).
MilliporeSigma™ Calbiochem™ CFTR Activator, Cact-A1
A cell-permeable, non-toxic aminopyrazolocarbonitrile compound that acts as a potent, selective, reversible and cAMP-independent activator of CFTR-dependent Cl- channel in airway epithelial cells (EC50
MilliporeSigma™ Calbiochem™ MPS1 Inhibitor III, AZ3146
A cell permeable purinone derivative that acts as a highly potent and selective inhibitor of monopolar spindle 1 kinase (MPS1; IC50 = ∽35
MilliporeSigma™ Calbiochem™ AAA-ATPase Drg1 Inhibitor, Diazaborine
An anti-bacterial compound that targets NAD(P)H-dependent enoyl acyl carrier protein reductase (ENR) resulting in the inhibition of bacterial fatty acid synthase.
MilliporeSigma™ Calbiochem™ Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700
The Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 controls the biological activity of Rab7. This small molecule/inhibitor is primarily used for Membrane applications.
MilliporeSigma™ Calbiochem™ Spautin-1
A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC50 = 580nM) and USP 13 (IC50 = 690nM) deubiquitinating enzymes
MilliporeSigma™ Calbiochem™ (+)-Bicuculline
A potent allosteric antagonist of vertebrate GABAA recept
MilliporeSigma™ Calbiochem™ Phenylmethylsulfonyl Fluoride
Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.
MilliporeSigma™ Calbiochem™ PICK1 PDZ Domain Inhibitor, FSC231
The PICK1 PDZ Domain Inhibitor, FSC231 controls the biological activity of PICK1. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ PD 98059
PD 98059, CAS 167869-21-8, is a cell-permeable, selective & reversible inhibitor of MAP Kinase Kinase (MEK). Inhibits MAP Kinase activation and subsequent phosphorylation of MAP Kinase substrates.
MilliporeSigma™ Calbiochem™ InSolution™ SRT1720, HCl
A 25 mM (10 mg/650 μl) sterile-filtered solution of SRT1720, HCl in DMSO.
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MilliporeSigma™ Calbiochem™ Proteasome Substrate II, Fluorogenic
Fluorogenic proteasome substrate.
MilliporeSigma™ Calbiochem™ TLR1/TLR2 Agonist II, CU-T12-9
A diphenyl substituted imidazole based compound that directly and selectively targets TLR1/2 and induces their dimerization and activates TLR1 and 2 signaling leading to NF-κB and AP-1 activation ( K D = 182 and 478 nM, respectively; EC50
MilliporeSigma™ Calbiochem™ TRPV4 Agonist, GSK1016790A
A cell-permeable, potent, selective agonist of TRPV4 channel. Enhances Ca2+ flux in a variety of human and mouse cells (EC50 = 2.1 nM for human TRPV4).
MilliporeSigma™ Calbiochem™ RORγt Inverse Agonist II, GSK805
A cell-permeable, potent, non-toxic, inverse agonist of RORγt. Directly and reversibly interacts with the ligand binding domain of RORγt to block its transcriptional effects.